I am a postdoctoral fellow at the University of Washington, supervised by David Baker. I work on designing small proteins de novo that can bind and inhibit disease targets in cancer, Ebola, and malaria. I have also developed a high throughput screen measuring protein stability, leading to the first large scale testing of de novo protein design and many insights into the stability requirements of small proteins. For an introduction to my work on malaria, see my poster showing the design process and preliminary results. For an introduction to my work studying the folding and design requirements of small proteins, see my slides from my talk at RosettaCON 2015.
I completed my Ph. D. at the University of California, San Francisco in 2013, supervised by Brian Shoichet and Ken Dill (now of Stony Brook University). My Ph. D. work examined how free energy calculations could be used to predict protein-ligand binding affinities, with a particular focus on charged compounds and finite-size artifacts. I made a short video explaining this work to a general audience, seen here on YouTube. During this research I worked closely with David Mobley and Philippe Hünenberger. More details can be found on my Research page.
My research in the Baker Lab is supported by a postdoctoral fellowship from the Life Sciences Research Foundation, sponsored by Merck.
University of Washington, Molecular Engineering and Sciences
Seattle, WA 98195-1655