I am a postdoctoral fellow at the University of Washington, supervised by David Baker. I work on designing small proteins de novo that can bind and inhibit disease targets in cancer, Ebola, and malaria. These simplified, designer proteins may also provide a route to novel insights into protein folding thermodynamics. For an introduction to my work on malaria, see my recent poster showing the design process and preliminary results.
I completed my Ph. D. at the University of California, San Francisco in 2013, supervised by Brian Shoichet (now returned to UCSF) and Ken Dill (now of Stony Brook University). My Ph. D. work examined how free energy calculations could be used to predict protein-ligand binding affinities, with a particular focus on charged compounds and finite-size artifacts. I made a short video explaining this work to a general audience, seen here on YouTube. During this research I worked closely with David Mobley and Philippe Hünenberger. More details can be found on my Research page.
My research is supported by a postdoctoral fellowship from the Life Sciences Research Foundation, sponsored by Merck.
University of Washington, Molecular Engineering and Sciences
Seattle, WA 98195-1655