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Gabriel Rocklin


I am a postdoctoral fellow at the University of Washington, supervised by David Baker. I am interested in developing new, massively parallel approaches for studying protein biophysics, and new protein design methods that can exploit massively parallel experiments. As an example, I designed 15,000 de novo miniproteins and assayed them for folding in high-throughput, revealing the determinants of stability and guiding improvement of the computational design method. This work was recently published in Science. I am also pursing new applications of engineered miniproteins to inhibit disease targets in cancer, asthma, and malaria. For an introduction to my work on malaria, see my poster showing the design process and preliminary results.

I completed my Ph. D. at the University of California, San Francisco in 2013, supervised by Brian Shoichet and Ken Dill (now of Stony Brook University). My Ph. D. work examined how free energy calculations could be used to predict protein-ligand binding affinities, with a particular focus on charged compounds and finite-size artifacts. I made a short video explaining this work to a general audience, seen here on YouTube. During this research I worked closely with David Mobley and Philippe Hünenberger. More details can be found on my Research page.

My research in the Baker Lab is supported by a postdoctoral fellowship from the Life Sciences Research Foundation, sponsored by Merck.


Gabriel Rocklin
University of Washington, Molecular Engineering and Sciences
Box 351655
Seattle, WA 98195-1655